Arturo Di Napoli stated that before Vicario moved to the Premier League, he was in talks with Inter, and Di Napoli is certain of this. According to Di Napoli, the deal failed only for economic reasons and Empoli consequently gave the player to Tottenham. Di Napoli said that Inter had wanted Vicario for a long time and that it would have been an important signing if Vicario had joined Inter.

Guglielmo Vicario is prepared to return to Serie A at the end of the 2025-26 season, and Spurs might be open to his sale. La Gazzetta dello Sport reports that Inter Milan is considering Vicario as the club anticipates changes in its goalkeeping department. It is reported that a desire to return to play in his home country's top league has persuaded Vicario to contemplate a transfer. Yann Sommer, who is Inter's current first-choice goalkeeper, has a contract that expires next year, and the club appears to be planning to overhaul its goalkeeping options. Vicario is now being seriously considered as a primary candidate for that position. Tottenham might be willing to sell Vicario for approximately €25-30 million, and this valuation would serve as a compromise to compensate Spurs while also fitting within Inter's budget.

According to 'Gazzetta dello Sport', there has been contact between Inter Milan and Guglielmo Vicario from Tottenham Hotspur. The Italian sports newspaper reports that around 30 million euros would be required for the 29-year-old. The report states that the goalkeeper was a subject of interest at Inter even before his move to Tottenham in 2023. The report adds that the expiring contract of Inter's current number one will not be extended, and they will separate in the summer.

In the summer of 2023, Tottenham Hotspur acquired Guglielmo Vicario for a fee slightly exceeding £17 million. Despite the investment, his performance has surpassed expectations, establishing him as a key player for the team. Recently, there have been reports linking Vicario to a potential return to Serie A, with Inter Milan expressing interest in securing his services. While it is believed that Vicario is considering remaining with Spurs, speculation suggests that the team might be tempted to sell if offers surpass £50 million. However, considering his swift impact at the club, the board would reportedly be hesitant to sanction his departure.